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We are looking for a capable and motivated postdoctoral candidate interested in research on metabolism, with an emphasis on the study of leukaemia and the tumour microenvironment.

The CLIP laboratories (Childhood Leukaemia Investigation Prague) are an integral part of the Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University in Prague. It is the largest paediatric oncology centre in the Czech Republic, with approximately 250 newly diagnosed patients annually. CLIP laboratories are responsible for diagnostics, monitoring disease progression, and treatment efficacy in haematological malignancies. In addition to diagnostics, CLIP also conducts internationally recognized research in the field of haematological diseases. One of CLIP’s specific interests is to elucidate the role of tumour metabolism in disease progression and treatment. Previous work led by Dr. Starková has highlighted the importance of new findings in this area (Hermanová, Leukaemia 2016; Hložková, BMC Cancer 2020; Hložková, Sci Rep 2022; Alquezar-Artieda, Blood Adv. 2023; Lukeš, Hemasphere 2023; Hložková, Cancer Lett. 2024). The long-term goal of the work is to use new insights in the interpretation of clinical data and potentially contribute to therapeutic interventions for patients with poor prognosis.

The current project focuses on identifying metabolic processes of resistant cells responsible for the adverse effects of current treatment. In this study, we use PDX models, single-cell RNA sequencing, mass cytometry, metabolic and proteomic tools, and ex vivo drug testing.

Your profile:

• Ph.D. in a relevant field (molecular biology, biochemistry, cell biology, immunology, or related disciplines)
• Enthusiasm for science
• Ability to work independently and lead a project
• Expertise in flow cytometry, microscopy, and in vivo models welcome
• Experience and willingness to also perform routine laboratory tasks
• Team player within our research group and with collaborators from other institutions
• Experience with presenting and publishing scientific work
• Experience supervising students in scientific work
• Advanced knowledge of English

We offer:

• Work on interesting projects in the field of leukaemia metabolism research
• Access to state-of-the-art technologies, including metabolic and transcriptomic methods at the single-cell level in in vitro and in vivo models
• High-quality scientific environment with the possibility to publish in prestigious journals
• Workplace with very good infrastructure and a friendly environment
• Top-quality research in a highly productive and internationally recognized institution
• Financial support for projects from various grant agencies
• Participation in international conferences
• Duration: 3 years
• Expected start date: March 2026
• Employee benefits

We look forward to receiving your cover letter and professional CV.